Villa Certano is easily reached via the A1 Autostrada del Sole motorway and the Firenze-Siena highway.

Following the A1 from the North, exit at Firenze Certosa, take the Firenze-Siena highway and continue until the Siena Ovest exit.

Following the A1 from the South, exit at Bettolle, take the Perugia-Siena-Firenze highway in the direction of Siena and continue until the Siena Ovest exit.

Exit at Siena Ovest and take the SS73 road in the direction of Massa Marittima-Monticiano, passing through the towns of Costafabbri and Costalpino.

Just about a kilometre past Costalpino you come to a church on the right and a big building on the left, then, after about a 100 metres, there is a road on the right bearing a sign for Certano. Once on this country road, keep to the left and continue along a tree-lined avenue leading to the estate of Villa Certano.